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A 30-year-old man presented with sagittal sinus thrombosis.He had a history of multiple thrombotic events since adolescence,and his father had had a similar history.Laboratory studies revealed the complete absence of free protein S in his plasma.Protein S deficiency,an autosomal dominant disorder,is an identifiable cause of cerebral thrombosis.The literature and our experience with this case suggest that long-term anticoagulant therapy may prevent thrombotic episodes in patients with this disorder. |
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